Analgesic and Anti-Inflammatory Activities of The Ethanol Leaf Extract of Justicia Insularis (T. Anders) on Albino Rats

Oyomah G.O, Odoemena C.S, Ogede R.O, Bala. D


The ethanolic leaf extract of Justicia insularis (T. Anders) was evaluated for its analgesic and antiinflammatory properties using acetic acid-induced writhing and thermal (hot plate) methods for analgesic activity and egg albumen-induced oedema as a model of acute inflammation respectively. 100mg/kg Bodyweight per day of Acytyl Salicyclic acid. (ASA) was used as standard drug for analgesic. Phytochemcial screening of the plant extract gave positive tests for saponins, alkaloids, tannins, flavonoids, anthraquinones and cardiac glycosides. The extract was dose-dependent and significantly at (P = 0.05). The median Lethal dose (LD50) was determined by intraperitoneal route which was calculated to be 2,449.49mg/kg using Lorke method. The experimental design used was a complete randomized type for all the studied parameters. The result further justified the use of J. insularis in herbal medicine for treatment of pains. 


Justicia insularis, Analgesic anti-inflammation, Acetyl Salicyclic acid (ASA)

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