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A mini review on synthesis of some pyrimidine analogues for its biological activities

Mohammad Asif

Abstract


Pyrimidine and their derivatives are endlessly pulling attention of the medicinal chemists in view of long and notable history extending from the day of their discovery as, important constituents of nucleic acid. The important pyrimidine compounds have diverse applications as bactericidal, fungicidal, anti-inflammatory, antihypertensive, analgesic, antiviral , antimalarial, antifilarial, antioxidant, anthelmintic, anti-HIV and anti tumor agents. They are also used as calcium channel blockers, α-antagonist and neuropeptide antagonist. Alkaloids containing the dihydropyrimidine structure have been isolated from various marine sources which have displayed interesting biological activities.


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