Synthesis of Phenylhydrazine substituted Schiff’s Base Containing Hybrid of 3,4-methylenedioxy: Future Non-steroidal Anti-inflammatory Candidate

Debarshi Kar Mahapatra, Kavita R Pandey, Disha M Dhabarde


In the previous research, a Schiff’s base containing 3,4-dioxymethylene based compound; (Z)-4-(2-aminoethyl)N-(1-(benzo[d][1,3]dioxol-5-yl)ethylidene)aniline was synthesized and screened for anti-inflammatory activity. But, the study highlighted a quite low edema reducing potential of the compound and it alarmed us that this “lead” right away needs further optimization and more rational designing. To overcome the challenges imposed in front of us, we decided to add an active low-molecular-weight ligand ‘phenylhydrazine’ with a strong belief that the addition of this ligand may successfully augment the edema reducing activity. In the present research, a continued approach was taken into account for enhancing the activity of Schiff’s base containing 3,4-dioxymethylene based compound by substituting phenylhydrazine group. The phenylhydrazine containing compound was similarly screened for determining the edema reducing activity in Swiss albino rats, utilizing the carrageenan-induced paw edema protocol. The experimental molecule expressed remarkable anti-inflammatory activity in comparison to the positive control, indomethacin. The study has opened new doors of research and will positively draw the attention of the fellow active researchers across the globe with a strong conclusive message that by the simple addition of a low-molecular-weight fragment to the existing substrate(s), the biological activity can be amplified by several folds.


3, 4-dioxymethylene, Anti-inflammatory, Edema, Schiff’s base, Phenylhydrazine, Synthesis

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Mahapatra DK, Bharti SK. Drug Design. New Delhi: Tara Publications Private Limited, 2016.

Mahapatra DK, Bharti SK. Handbook of Research on Medicinal Chemistry: Innovations and Methodologies. New Jersey: Apple Academic Press, 2017.

Mahapatra DK, Shivhare RS. 3′,4′-Methylenedioxy Moiety Containing Murrayanine Based Chalcone as Emerging Anti-inflammatory Agent. J Mod Chem Chem Technol 2018; 9(1): 12-16.

Mahapatra DK, Thote LT, Dhabarde DM. The emerging anti-inflammatory potentials of some novel Schiff’s base derivatives of 3,4-dioxymethylene acetophenone. J Appl Pharm Sci Res 2018; 1(3): 1-4. 5. Chhajed SS, Upasani CD, Wadher SJ, Mahapatra DK. Medicinal Chemistry. Nashik: Career Publications Private Limited, 2017.

Mahapatra DK, Taleuzzeman M, Dutta SD. Novel 2-((2-(4-substituted-phenyl)hydrazinyl)methyl) isoindoline-1,3-dione derivatives as anti-microbial agents: Part-I of Research. Pharmacol Pharm Rep 2018; 1(2): 1-5.

Kanhed AA, Mehere AP, Pandey KR, Mahapatra DK. 4-(2-chloroacetamido) Benzoic Acid Derivatives as Local Anesthetic Agents: Design, Synthesis, and Characterization. UK J Pharm Biosci 2016; 4(6): 35-44.

Mahapatra DK, Shivhare RS, Kumar P. Murrayaninechalcone transformed into novel pyrimidine compounds demonstrated promising anti-inflammatory activity. Asian J Pharm Res 2018; 8(1): 6-10.


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